L I P

Laboratório de Instrumentação e Física Experimental de Partículas

L I P

L I P [PARTICLES AND TECHNOLOGY]

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ICNAS

Beam Monitoring System for Cyclotron Proton Beams at ICNAS


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The group at LIP develops this project in collaboration with ICNAS, the structure belonging to the University of Coimbra that hosts a proton cyclotron for applications in nuclear medicine. The collaboration has already moved forward in its goals in several aspects related with (1) instrumentation for proton beam measurements, and (2) automatic irradiation and quantification of doses of several Gy down to one hundred mGy. The final goal of the project is to provide the end user with a setup offering the possibility of carrying out proton dosimetric experiments together with small-animal radiotherapy studies. One of the goals of the project is to allow studies in the field of radiotherapy comprising total doses between a few cGy to a few Gy, as well as studies in the field of radiation protection, hence comprising doses of the order of a few hundreds down to tens of mGy.

In 2014 several developments were accomplished within the aforementioned objectives. We are now able to control a homogeneous beam spot on target with a diameter of 16 mm, and excluding the (computed) outer skirts of the beam where non-homogeneity occurs. This was intended in order to allow the controlled irradiation of cell cultures located in typical biological multi-well dishes with diameters of 16 mm. The control of the magnetic field applied inside the cyclotron plays a major role for achieving said homogeneity. A scan revealing a quasi-gaussian shape must be performed before any irradiation, with the final shutter closed, so that the optimum magnetic field can be applied hence producing a homogeneous target dose. Inhomogeneity quantification is ongoing, with first results pointing to values inferior to +/- 3%. A setup for cell-culture irradiation has also been constructed. Plans are to perform first dose-survival curves soon.

// Research Area
Física Experimental de Partículas com aceleradores
Contacts
Group Leader:  
Paulo Crespo

crespo@lip.pt


 


  • Development of a PET cyclotron based irradiation setup for proton radiobiology
  • Author(s):  Sharif Ghithan, Paulo Crespo, S.J.C. do Carmo, Rui Ferreira Marques, F.A.F. Fraga, Hugo Simões, Francisco Alves, P.J.B.M. Rachinhas
  • Publication:  2015-02-19
  • Reference:  JINST 10, P02010, 2015   View publication

  • Fast and precise verification of proton beam position, range, and dose by using a plastic scintillator at PET-dedicated cyclotrons
  • Author(s):  S. Ghithan, S.J.C. do Carmo, F. Alves, R. Ferreira Marques, F. Fraga, H. Simões, P. Crespo
  • Submission:  2013-11-15, Acceptance:  2013-11-15, Publication:  2013-11-15
  • Reference:    

  • On-line measurements of proton beam current from a PET cyclotron using a thin aluminum foil
  • Author(s):  S. Ghithan, S.J.C do Carmo, R. Ferreira Marques, F.A.F Fraga, H. Simões, F. Alves, P. Crespo
  • Submission:  2013-06-11, Acceptance:  2013-06-27, Publication:  2013-07-24
  • Reference:  JINST 8 P07010   View publication

  • Preliminary Characterization of the External Proton Beam from a PET Cyclotron for use in Neutron and Proton Radiobiology and Other Dosimetric Studies
  • Author(s):  Sharif Ghithan, Hugo Simoes, Francisco Alves, Sergio Carmo, Micaela Cunha, Rui Ferreira Marques, Francisco Fraga, Marco Pinto, Paulo Crespo
  • Submission:  2012-12-31, Acceptance:  2012-12-31, Publication:  2012-12-31
  • Reference:  2012 IEEE 2nd Portuguese Meeting in Bioengineering (ENBENG)  

View all the group publications


  • ANTS
  •  Anger camera-type detector simulation and experimental data processing tools.
  •     website


View all the group publications



Paulo Crespo
Coimbra
Researcher

Rui Marques
Coimbra
Researcher

 
 

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Laboratório de Instrumentação e Física Experimental de Partículas   LIP.PT

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